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In my 05 cs I had installers replace the head unit with an after market double din nav. Also put in a 4channel amp to bypass the bose amp and also a sub amp. Sounds awesome! I kept all the bose speakers.
As far as changing out the speakers I would assume you would need to swap out the bose amp. If I am correct bose runs their speakers at a really odd ohm load. Like 1 ohm or so. Almost all after market speakers are 4ohm. Also once you do swap out the amp, the bose amp uses a fiber optic cable to power the stock amp. So you may have to swap out your head unit to intergrate into it.
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